Researchers at the University of Szeged and the University of Pécs have developed and started to use a unique microscope system. The method can greatly increase the use of conventional optical microscopes, ie they can visualize structures and biological objects up to 20 nanometers.
to study the transport of matter between cells, to monitor the recovery system of DNA in the nucleus, or to discover, for example, molecules that cause Alzheimer’s disease.
Over four years, participate. The development and application of combined microscopic methods allows for non-destructive and distortion-free, real-time in vivo measurements. The aim of the project is to create the possibility of measurements on individual particles and objects, as measurements on isolated particles can pave the way for understanding the processes taking place at the molecular level.
“We plan to apply applications based on our results. The new high-resolution method, based on super-resolution microscopy, is suitable for automated measurement with a special image capture and image processing method, which makes it possible to determine and examine individual nucleosomes, among other things. “We can get an idea of the defective processes that can cause tumour genesis microtubules if DNA repair does not work properly. Some of the results of the research have already been integrated into undergraduate and doctoral training,” Institute of Physics, University of Szeged and Head of the Department of Quantum Electronics
A confocal (common focal point) and a high-resolution SIM microscope with different laser lines and software were installed to carry out the research. Thus, the traditional microscope became unique and the microscopic techniques they used revealed that the transport processes are controlled by the main proteins of the cell skeleton, the filamentous actin, and the microtubular system, and that the immunological synapse revealed nanotube networks
The research has yielded a number of results. One of these was the development of innovative drug-containing powder inhalation formulations using laser technique and co-spraying for the modern therapeutic treatment of lung diseases (cystic fibrosis, TB, pneumonia). In addition, the researchers have developed a method based on a special laser material processing form, which can be used to efficiently produce submicrometer drug particles in order to increase the input efficiency.
According to SZTEinfo HUF 31 million was realized from European Union support. The GINOP-2.3.2-15-2016-00036 research project started on 1 January 2017 and ended on 30 June 2021.
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