Introduction

The results of a scientific study conducted by scientists from the Foresight Institute showed how dangerous periodontitis is for the brain.

Oral Diseases and Alzheimer’s

Journal notes of Neuroinflammation indicates that oral diseases can lead to Alzheimer’s disease.

Research on Brain Cells

Previous research has linked gingivitis to an inflammatory response in the brain. In this study, the researchers focused on the changes that can occur in brain cells when pathogenic bacteria are present in the oral cavity. To do this, they studied microglia, the white blood cells that clear amyloid plaques associated with Alzheimer’s disease.

Experiments on Laboratory Mice

The researchers conducted experiments on laboratory mice, during which they tracked the bacteria in the oral cavity that cause gingivitis. They confirmed that these bacteria had reached the brain and then identified glial cells in the brain that had been exposed to oral bacteria.

Hyperactivity of Glial Cells

The researchers found that the presence of pathogenic bacteria in the oral cavity leads to hyperactivity of glial cells, which stimulates inflammation of the nerves and prevents the destruction of amyloid plaques. In other words, the presence of inflammation in the gums allows microorganisms to enter the bloodstream and enter other parts of the body, including the brain.

Implications for Alzheimer’s Prevention and Treatment

According to the researchers, this discovery allows for more effective strategies for the prevention and treatment of Alzheimer’s disease. That is, to prevent neurodegeneration, it is very important to control the inflammation of the oral cavity associated with periodontal disease.

Source

Source: Linta. EN